This will be fairly brief. And, fortunately, in the Internet age is less relevant than it once was.
If you smoke (or live with someone who does), think long and hard about sending out any printed stories or manuscripts from your house.
I’m not a smoker, but my mother is. She’s had a printout of my manuscript for the past six weeks or so while she reviewed it for me. Sitting here, thumbing through the pages, I can smell the cigarette smoke.
Since it’s valuable to me to read these pages (she’s a genius at finding little word errors like should instead of shoulder or house instead of horse), I am. But if I were an agent or editor, I might very well decide that the story I was reading really wasn’t good enough to stand six hours of smelling cigarette smoke.
It wouldn’t be something I would consciously do, but I suspect you’d have to be an even better writer than everyone else to pass that small smell hurdle for me.
Something to think about. You’d be amazed how much cigarette smell seeps into everything.